KIT cITD induces apoptosis resistance when treated with IM, Rap, and LY294002 in transformed Ba/F3 cells that can be overcome by a combination of IM and Rap. Ba/F3 WT and Ba/F3 kit cITD cells were treated with the indicated doses of IM and Rap (alone and in combination) and LY294002, for 24 hours and 48 hours. Apoptosis was determined via analysis of DNA fragmentation of propidium iodide-stained nuclei. Error bars indicate standard deviation.