Figure 1.
Figure 1. VWF antigen levels in plasma after tail vein administration of murine VWF cDNA to VWF–/– mice. VWF antigen levels at 48 hours, 72 hours, and 1 week after VWF cDNA injection, respectively. Results were determined by ELISA, as described in “Materials and methods,” and are reported as percentages of normal murine VWF. Profiles are shown for plasma VWF antigen level from untreated wild-type mice, plasma VWF antigen level from untreated VWF–/– mice, plasma VWF antigen level after injection of 50, 100, or 250 μg murine VWF cDNA, plasma VWF antigen level after injection of 10 μg recombinant human VWF protein, plasma VWF antigen level after injection of 250 μg eGFP cDNA (negative control), and plasma VWF antigen level after hydrodynamic injection of saline (negative control).

VWF antigen levels in plasma after tail vein administration of murine VWF cDNA to VWF–/– mice. VWF antigen levels at 48 hours, 72 hours, and 1 week after VWF cDNA injection, respectively. Results were determined by ELISA, as described in “Materials and methods,” and are reported as percentages of normal murine VWF. Profiles are shown for plasma VWF antigen level from untreated wild-type mice, plasma VWF antigen level from untreated VWF–/– mice, plasma VWF antigen level after injection of 50, 100, or 250 μg murine VWF cDNA, plasma VWF antigen level after injection of 10 μg recombinant human VWF protein, plasma VWF antigen level after injection of 250 μg eGFP cDNA (negative control), and plasma VWF antigen level after hydrodynamic injection of saline (negative control).

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