Figure 1.
Figure 1. Antifolate growth inhibition of parental human leukemia CCRF-CEM cells and their various PT523-resistant sublines. Exponentially growing parental CCRF-CEM (WT, ○) cells and their various PT523-resistant sublines PTR0.03 (•), PTR0.05 (▪), and PTR0.5 (▴) were exposed to increasing concentrations of GW1843 (A) or pemetrexed (MTA) (B) as detailed in “Materials and methods.” Following 3 days of incubation at 37°C, viable cell counting was performed using trypan blue exclusion. Values depicted represent means ± SD of 3 to 5 independent experiments.

Antifolate growth inhibition of parental human leukemia CCRF-CEM cells and their various PT523-resistant sublines. Exponentially growing parental CCRF-CEM (WT, ○) cells and their various PT523-resistant sublines PTR0.03 (•), PTR0.05 (▪), and PTR0.5 (▴) were exposed to increasing concentrations of GW1843 (A) or pemetrexed (MTA) (B) as detailed in “Materials and methods.” Following 3 days of incubation at 37°C, viable cell counting was performed using trypan blue exclusion. Values depicted represent means ± SD of 3 to 5 independent experiments.

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