Changes in MAP and HR for each study group. (A) NOS inhibition. Both the increase in MAP and the decrease in HR were statistically significant from baseline at all time points. (B) CFH concentration. MAP was statistically increased by PBH and PBH4 compared with saline at all time points, but increases were not statistically different from each other. (C) CFH molecular configuration. MAP was statistically increased by all CFHs compared with saline (P < .05), but no statistical differences were obtained between the groups at each time point. All data are shown as mean ± SEM. Parameters are presented as change relative to baseline, thus no change from baseline would be denoted as 0, while 0.1 would mean a 10% increase from baseline. MAP changes within each experimental group were all statistically significantly different from baseline except for saline (P < .05; this significance is not denoted in the graphs). The asterisk is used to denote the statistical significance at each time point between the experimental groups (P < .05).