Figure 5.
Figure 5. Destruction of ovalbumin-expressing β cells by TCR-transduced T cells. RIP-OVAhi mice received 1 × 106 F5 (left) or OT-I (right) transduced T cells followed by rVV-OVA infection. Mice were treated with insulin implants upon onset of diabetes, and pancreata were harvested 3 months after transfer. Three nonserial sections per mouse were assessed for ovalbumin-positive islands by immunohistochemistry. Per section, the number of islets per view was counted using ×2.5 magnification. Shown are (A) 2 representative sections and (B) the average numbers of islets per view for mice that received F5 or OT-I TCR-transduced T cells. Original magnification, ×5.

Destruction of ovalbumin-expressing β cells by TCR-transduced T cells. RIP-OVAhi mice received 1 × 106 F5 (left) or OT-I (right) transduced T cells followed by rVV-OVA infection. Mice were treated with insulin implants upon onset of diabetes, and pancreata were harvested 3 months after transfer. Three nonserial sections per mouse were assessed for ovalbumin-positive islands by immunohistochemistry. Per section, the number of islets per view was counted using ×2.5 magnification. Shown are (A) 2 representative sections and (B) the average numbers of islets per view for mice that received F5 or OT-I TCR-transduced T cells. Original magnification, ×5.

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