Prevalence of KD mutations in resistant cell clones. ENU-treated Ba/F3-p210^BCR-ABL cells were cultured in the presence of graded concentrations of nilotinib, dasatinib, or imatinib mesylate. (A) At higher drug concentrations, only KD mutant clones were detected. (B) T315I is the single mutation that persists in highest concentrations of nilotinib and dasatinib.