NOTCH1 mutations in patients with precursor T-cell ALL of the ALL-BFM 2000 study. (A) NOTCH1 HD-N domain mutations. Missense and deletion mutations (top panel) and insertions (bottom panel) located between positions 1571 and 1642. The mutated amino acid residues are indicated. Novel NOTCH1 mutations are indicated by an asterisk next to the sample identification number. Deletions are indicated by dashes (–). (B) NOTCH1 HD-C domain mutations. Missense mutations (top panel) and insertion (bottom panel) located between positions 1674 and 1723. The mutated amino acid residues are indicated.