Effect of NOTCH1 mutation status on long-term prognosis in T-ALL. One-hundred fifty-seven children with precursor T-ALL of the ALL-BFM 2000 study were classified according to either the presence or the absence of NOTCH1 mutations. (A) Kaplan-Meier estimate of event-free survival (EFS) at 4 years. (B) Cumulative incidence of relapse.