Correction of abnormal RBC morphology in –383 γ-β^A–corrected mice. (A) Blood smear of an hβ^A/hβ^A control. (B) Blood smear of an hβ^S/hβ^S sickle animal with characteristic sickled erythrocytes and a pronounced reticulocytosis. (C) Blood smear of an hβ^A/hβ^S-corrected mouse. No sickled cells were observed in any field examined. Blood smears were stained with Wright-Giemsa and the magnification is 100×/1.40 NA oil objective (Nikon Eclipse E800 inverted microscope [Nikon, Tokyo, Japan], Hamamatsu C5810 Color Chilled 3CCD camera [Hamamatsu City, Japan]; Adobe Photoshop CS version 8.0 imaging software [San Jose, CA]). Data from –1400 γ-β^A–corrected mice are identical to –383 γ-β^A–corrected animals.