Molecular characterization of deletion, del(11)(p12p13), in 6 pediatric T-ALL patients. Chromosome 11 ideogram and corresponding oligo array-CGH plot of test DNA/control DNA ratios (blue tracing) versus the dye-swap experiment (red tracing) for T-ALL patient 1950 (A) and patient 2104 (D). Hybridization signals in the absence of amplifications or deletions scatter around the “zero” line, indicating equal hybridization for patient and reference DNA. Hybridization signals around the -2X or +2X lines represent loss of the corresponding region in the patient DNA. Detailed analysis of the telomeric breakpoints in patients 1950 (B) and 2104 (E) and the centromeric breakpoints in patients 1950 (C) and 2104 (F) of the deletion, del(11)(p12p13). (G) Overview of oligo array-CGH results in the potential breakpoint regions for 4 DCOG and the 2 COALL T-ALL patients with del(11)(p12p13). The 60-mer oligos present on the DNA array and located in the telomeric and centromeric breakpoint regions, as well as the specific genes located in this region with their transcription direction, are shown. N indicates normal; L, loss; and U, noninformative.