The GEP of WM is closer to CLL than MM. (A) Using 2162 gene probes that are variably expressed across the WM, CLL, and MM samples, unsupervised clustering of these samples together with normal B cells, PCs, MGUS, and SMM was performed. Selected genes that clustered together and were overexpressed in different sample clusters are highlighted. Restricting our analysis to only WM, CLL, and MM samples, unsupervised clustering was performed using published (B) CLL and (C) MM signatures. WM samples clustered predominantly with CLL samples and also exhibited closer approximation of the GEP using both signatures to CLL. Some genes of interests are highlighted. In both heatmaps, the colored bar at the bottom indicates the tumor type: blue, CLL; yellow, WM; and red, MM. The scale of the gene-expression data are similar to that in panel A.