Figure 3.
Sequential blood chimerism after BM infusion with leukocyte-depleted intestine grafts. (A) Donor BN cells in LEW recipients of leukocyte-depleted intestine grafts without donor BM infusion became undetectable by day 120. (B) In contrast, donor BM infusion together with transplantation of leukocyte-depleted intestine grafts resulted in persistent macrochimerism. ALS indicates donor ALS pretreatment for 3 days (1.0 mL; day –3 to –1); Rad, ex vivo 9.5 Gy graft irradiation. *P < .05 versus naive SITx (without lymphoid depletion); δP < .05 versus corresponding group without donor BM at the same time point.