Bortezomib-induced aggresome formation and LBH589-induced α-tubulin hyperacetylation are augmented in combination. Patterns of α-tubulin acetylation and aggresome formation were classified as described in “Materials and methods.” Cell counts were performed on at least 150 cells in each treatment group. Morphologic patterns defined by acetyated α-tubulin were further classified based on nuclear appearance to be either normal or apoptotic. A representative set of counts from 3 separate experiments is shown. Data represent means ± SD.