Schematic representation of upstream cytoskeletal events when bortezomib and LBH589 are combined. (A) Viable plasma cell with reticulated acetylated α-tubulin. (B) Aggresome formation in the presence of bortezomib. Aggregates of misfolded proteins are directed along the acetylated α-tubulin fibrils toward a single perinuclear region, forming the aggresome. This process requires TDAC activity. (C) In the presence of bortezomib in combination with LBH589, aggresome formation is diminished, bundles of hyperacetylated α-tubulin form, and the cell undergoes apoptosis.