American Society of Hematology

Figure 5.

$Figure 5. Locomotion of transmigrating wt and DOCK2–/– T cells underneath the endothelial layer. Lymphocyte motion underneath the endothelial monolayer was tracked immediately after completing TEM. The fraction of transmigrating wt or DOCK2–/– T cells that successfully locomoted for at least 3 cell diameters on the basal substrate away from the TEM site is depicted for each population. (Inset) Tracks of 3 individual wt and DOCK2–/– T cells taken immediately after TEM completion. Black dots denote the sites of the lymphocyte TEM, and white lines denote the lymphocyte locomotion tracks after TEM underneath the endothelium. Bar = 30 μm. Results are representative of 5 independent experiments.$

Locomotion of transmigrating wt and DOCK2^–/–T cells underneath the endothelial layer. Lymphocyte motion underneath the endothelial monolayer was tracked immediately after completing TEM. The fraction of transmigrating wt or DOCK2^–/– T cells that successfully locomoted for at least 3 cell diameters on the basal substrate away from the TEM site is depicted for each population. (Inset) Tracks of 3 individual wt and DOCK2^–/– T cells taken immediately after TEM completion. Black dots denote the sites of the lymphocyte TEM, and white lines denote the lymphocyte locomotion tracks after TEM underneath the endothelium. Bar = 30 μm. Results are representative of 5 independent experiments.

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