The antibody molecule, here shown as IgG1, contains 2 identical light chains (purple) and 2 identical heavy chains (green). The light chain consists of 1 N-terminal variable domain (VL) followed by 1 constant domain (CL). The heavy chain consists of 1 N-terminal variable domain (VH) followed by 3 constant domains (CH1, CH2, and CH3). The antigen-binding site results from the convergence of 6 CDRs, 3 provided each by VL and VH. F(ab′)2 and Fc fragments of the antibody molecule are indicated. Illustration by Paulette Dennis.

The antibody molecule, here shown as IgG1, contains 2 identical light chains (purple) and 2 identical heavy chains (green). The light chain consists of 1 N-terminal variable domain (VL) followed by 1 constant domain (CL). The heavy chain consists of 1 N-terminal variable domain (VH) followed by 3 constant domains (CH1, CH2, and CH3). The antigen-binding site results from the convergence of 6 CDRs, 3 provided each by VL and VH. F(ab′)2 and Fc fragments of the antibody molecule are indicated. Illustration by Paulette Dennis.

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