Figure 1.
Plasma cell response to immunization. (A) MenC polysaccharide vaccine. (B) MenC polysaccharide/CRM197 conjugate vaccine. Subjects were immunized on day 0, and PBMCs were separated on various days after immunization. Numbers of subjects whose PBMCS were obtained for ELISpot for each day after immunization are given in the tables below each panel. Different children were studied at each time point. B-cell numbers are expressed as MenC-specific ASCs per 2 × 105 PBMCs. Horizontal bars represent the median number of MenC-specific ASCs at each time point. Blank cells indicate days on which no blood samples were taken.
