Figure 7.
Dectin-1 promotes IL-6, RANTES, and G-CSF production in mycobacterial-infected BMMϕs. Cells were infected with M smegmatis and M bovis BCG (A) or M avium 724 and M avium 2151 (B) in the presence of PBS or anti–dectin-1 mAb 2A11 or isotype control Ab as described in Figure 6. Culture supernatants were analyzed for G-CSF, RANTES, and IL-6 by ELISA. Values are expressed as means + SD. Data are representative of 3 separate experiments. Smeg indicates M smegmatis; 724, M avium 724; 2151, M avium 2151; RC, noninfected BMMϕs; and Iso-Control, isotype control Ab. *Significant to mycobacteria plus PBS.