Figure 1.
Figure 1. Btk is required for GPIb-elicited TxA2 production and ATP secretion by bt/VWF-stimulated washed platelets. (A) Aggregation and agglutination traces of wild-type (WT) and Btkxid/Y platelets treated with 0.5 μg/mL bt and 10 μg/mL human VWF. (B) Levels of TxA2 production and ATP secretion elicited by a combination of agglutination and aggregation. Btkxid/Y platelets did not produce TxA2 or secrete ATP. Therefore, Btk is required for agglutination-elicited TxA2 production. The error bars represent standard deviation; n = 3.

Btk is required for GPIb-elicited TxA2 production and ATP secretion by bt/VWF-stimulated washed platelets. (A) Aggregation and agglutination traces of wild-type (WT) and Btkxid/Y platelets treated with 0.5 μg/mL bt and 10 μg/mL human VWF. (B) Levels of TxA2 production and ATP secretion elicited by a combination of agglutination and aggregation. Btkxid/Y platelets did not produce TxA2 or secrete ATP. Therefore, Btk is required for agglutination-elicited TxA2 production. The error bars represent standard deviation; n = 3.

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