Prolonged viremia in chronically infected SAP– mice. (A) Viremia in wild-type (WT) and SAP– mice was measured by LCMV plaque assay at day 16 after LCMVcl13 infection. Viral loads were similar in wild-type and SAP– mice (P > .05). (B) Viremia in wild-type and SAP– mice was measured by LCMV plaque assay at day 30 after LCMVcl13 infection. Viral loads were 3-fold higher in SAP– mice than in WT mice (P < .01). (C) Viremia was determined 60 days after infection by QPCR for LCMV genomes per milliliter. Viremia in SAP– mice was 10-fold higher than in WT mice (P < .007). Limit of detection was 103 copies per milliliter. (D) Viremia was determined 90 days after infection by QPCR for LCMV genomes per milliliter. Viremia in SAP– mice was 6-fold higher than in WT mice (P < .006). Composite data from 3 independent experiments are shown.
