![Figure 1. Study schema. (a) Cy 60 mg/kg per day, TBI total dose 13.2 Gy, fractionated as 165 cGy twice daily for 4 days; (b) busulfan 1 mg/kg per dose given 4 times daily, Cy 60 mg/kg per day; (c) GVHD prophylaxis: cyclosporine A (in the Cy/TBI group) or cyclosporine A or tacrolimus (in the Bu/Cy group) starting day –3 in combination with methotrexate 15 mg/m2, IV bolus on day +1 and methotrexate 10 mg/m2, IV bolus on days 3, 6, and 11; (d) filgrastim 5 μg/kg per day from 24 hours after transplantation until neutrophil recovery (absolute neutrophil count [ANC], 1 × 109/L for 3 consecutive days, or 10 × 109/L for 1 day, whichever occurred first). K40 indicates palifermin 40 μg/kg per day; K60, palifermin 60 μg/kg per day; P, placebo; Cy, cyclophosphamide; Bu, busulfan; RT, radiotherapy.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/108/9/10.1182_blood-2006-04-017780/4/zh80210603190001.jpeg?Expires=1735557807&Signature=CwR8niO8bnRHvD7976Xs6gXhGKXsDlY4XeWPlMLxkVO1lWdOdtrAZmaTW25MI7itNd0SMOV0w6Ny7oGqgjBAit1RsirCgfp3tpy11z-xeQGumpnWT5vzUDD5gudPZ7E8LIFM6EHa9ZG46YUGWtIONQPSA3aJ6d33sp7OmoDjRic0~SBDwr8eel67XvWd~QhtTK9UMGhBc18h~j6IYOL1kak2CaKbQK5IN3r7hiw7FwL-LzWbDO1sobRPukLYGJtuGYsTLoqiYLFzL9do4CBJKU6oh9aBAEv5Df3UmVgw3dL5plbIUgSpKt~iyUlCT5nGbzAZ6hkRCYq8-~dkiTxFjw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Study schema. (a) Cy 60 mg/kg per day, TBI total dose 13.2 Gy, fractionated as 165 cGy twice daily for 4 days; (b) busulfan 1 mg/kg per dose given 4 times daily, Cy 60 mg/kg per day; (c) GVHD prophylaxis: cyclosporine A (in the Cy/TBI group) or cyclosporine A or tacrolimus (in the Bu/Cy group) starting day –3 in combination with methotrexate 15 mg/m2, IV bolus on day +1 and methotrexate 10 mg/m2, IV bolus on days 3, 6, and 11; (d) filgrastim 5 μg/kg per day from 24 hours after transplantation until neutrophil recovery (absolute neutrophil count [ANC], 1 × 109/L for 3 consecutive days, or 10 × 109/L for 1 day, whichever occurred first). K40 indicates palifermin 40 μg/kg per day; K60, palifermin 60 μg/kg per day; P, placebo; Cy, cyclophosphamide; Bu, busulfan; RT, radiotherapy.
