The effect of increasing hematocrit on whole-cell current recordings in P falciparum–infected RBCs. (A) Current recording of an infected RBC, V_H = 0 mV. (B) Current recording after increasing the hematocrit from 0.001% to 5%, V_H = 0 mV. (C) Current recording after changing V_H from 0 to –30 mV. (D) I-V curves derived from the data in panels A (○), B (□), and C (▵), averaged with 5 additional experiments. Current data are shown as the mean (SEM) and, where not shown, error bars lie within the symbols.