Induction of apoptosis and inhibition of cell-cycle progression of mutant FLT3-expressing cells by NVP-AST487. Effects of NVP-AST487 on viability of (A) FLT3-ITD-Ba/F3 cells, (B) FLT3-D835Y-Ba/F3 cells, and (C) parental Ba/F3 cells following 3 days of treatment. Effects of NVP-AST487 on cell-cycle progression of FLT3-ITD-Ba/F3 cells (D) following 36 hours of treatment.