EM011 inhibits tumor growth by triggering apoptosis. (A-D) Activated (cleaved) caspase-3 was examined by immunohistochemical staining of paraffin-embedded tumor sections from untreated control (A,C) and EM011-treated (B,D) mice. (E-H) Representative TUNEL-stained micrographs of tumor sections from untreated control (E,G) and EM011-treated (F,H) mice. Original magnification, × 200.