EM011 does not cause obvious pathologic abnormalities in normal tissues. (A-C) Hematoxylin and eosin staining of paraffin-embedded sections of the duodenum, liver, spleen, kidney (A), brain, heart, lung (B), and sciatic nerve (C). Original magnification, × 400 (objective, 40 ×/0.65 NA). Panels D and E show the white blood cells (WBC) and red blood cells (RBC) counts, and hemoglobin (HGB) concentrations, and hematocrit (HCT) values of mice bearing tumor xenografts; P < .05. Panels F and G show the levels of alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALK PHOS), and blood urea nitrogen (BUN) of mice bearing tumor xenografts.