Expression patterns of 52 genes differentially expressed in PCs of healthy donors (NPC) and patients with MGUS. Two-dimensional unsupervised hierarchical cluster analysis of 52 genes (rows) in CD138-enriched plasma cells from 22 healthy donors and 24 MGUS patients (columns). Mean-centered gene expression is depicted by a normalized-signal pseudocolor scale, as described.21 Red and green indicate overexpressed and underexpressed genes, respectively. Sample dendrogram (top), reflecting relatedness among samples, consists of 2 major branches defined by overexpressed and underexpressed genes. The left branch consists of 22 NPC samples (horizontal blue bar) and 2 MGUS samples (green arrows), whereas the right branch contains all MGUS (horizontal green bar) and a subset of 2 NPC samples (blue arrows).
