MGUS-L signature is present in most PCs of patients still alive more than 10 years after TT1. As in Figure 2, a 2-dimensional unsupervised hierarchical cluster analysis of 52 genes (rows) in CD138-enriched plasma cells from patients with MGUS (n = 56), MM from MGUS (n = 16), and newly diagnosed MM (n = 351, training cohort) and from 20 long-term survivors (columns). Long-term survivor samples are indicated by green arrows.