AIDE inhibits Akt and AP-1 pathways in HTLV-I–transformed cells. (A) Western blot analysis of AP-1 members JunD and JAB1 in C8166 cells after treatment with As₂O₃/IFN-α in the absence or presence of increasing doses of emodin and DHA. Actin was used to confirm equal loading. (B) Western blot analysis of Akt in C8166 cells treated with As₂O₃/IFN-α in the absence or presence of increasing doses of emodin and DHA. (C) Spot densitometry quantification expressed as the percentage of untreated control (100%) for Akt, JunD, and JAB1. (D) Proliferation assay of C8166 cells and PBMCs treated with As₂O₃/IFN-α and increasing doses of emodin and DHA.