Oncogenic Notch signaling pathways in hematologic malignancies. Activation of Notch modulates signaling pathways that increase proliferation and inhibit apoptosis, thus contributing to neoplastic transformation. T-ALL indicates T-cell acute lymphoblastic leukemia; MM, multiple myeloma; and B-CLL, B-cell chronic lymphocytic leukemia. Specific signaling pathways and abbreviations of signaling components are outlined in “The molecular and functional basis of Notch-induced oncogenesis.”