Figure 7.
CD79B promoter region is methylated in HRS cells of primary cHL. Methylation status of CD79B promoter was analyzed by bisulfite genomic sequencing. The sequenced region contained 9 CpGs. The first and last CpGs are at positions -5 and +106, respectively, counting from the start of transcription. The binding sites for Oct2, Sp1, and PU.1 are marked as filled circles, horizontal ovals, and vertical ovals, respectively. All other symbols and designations are the same as for Figures 5 and 6. The polymorphism/mutation in expected CpG dinucleotides is marked by X.