Figure 2
![Figure 2. Histologic analysis of [H2-Ab1−/− → C3H] mice showed pathologic features similar to human chronic GVHD. The histologic findings of the skin (A-B), liver (C-D), and salivary glands (E-F) from [WT → C3H] mice and [H2-Ab1−/− → C3H] mice are shown. Sclerodermatous skin changes, such as epidermal atrophy, fat loss, follicular dropout, and dermal thickness (B); bile duct loss and fibrosis in the portal area and mild periportal mononuclear infiltrates in the liver (D, arrow); and lymphocyte inflammation, fibrosis, and atrophy of acinar tissue in the salivary glands (F, arrow) were observed in [H2-Ab1−/− → C3H] mice (original magnification, × 100).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/109/4/10.1182_blood-2006-08-042853/4/zh80040708120002.jpeg?Expires=1735565984&Signature=kJT2n-jIl4zloz8uGyuhkseVQlFqK6nH-~Ok28Si3D5-gfaxi8b2IACl2tFzPR9KUXbOQ5B18f~4PQMyqzxbqJ3aZcsM8rpmydBtiSVWffUiuItdFbmJDfmXOZyWPGaEhCiw1r4PF-ZpwgUZKReCHRcje~HXcHDf9041EoFVqR-fVrIK6CEwW8ueNPRQO9sHfLQVocz31L0zcC3fj6esAw2xSjeFie9SQ8-Vm8~m0D0NjNiClEFqkdcFenA7CxIcdMYc-Bca7NrS9EaHBUaaG5m8WE5OVQLPTBuG5Y3Rz6vH3TPqnECfSWNnbmL8C1RPemIZGWVdJ9k3XZ7W3puGEQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Histologic analysis of [H2-Ab1−/− → C3H] mice showed pathologic features similar to human chronic GVHD. The histologic findings of the skin (A-B), liver (C-D), and salivary glands (E-F) from [WT → C3H] mice and [H2-Ab1−/− → C3H] mice are shown. Sclerodermatous skin changes, such as epidermal atrophy, fat loss, follicular dropout, and dermal thickness (B); bile duct loss and fibrosis in the portal area and mild periportal mononuclear infiltrates in the liver (D, arrow); and lymphocyte inflammation, fibrosis, and atrophy of acinar tissue in the salivary glands (F, arrow) were observed in [H2-Ab1−/− → C3H] mice (original magnification, × 100).
