Histologic analysis of recipients of [H2-Ab1^−/− → C3H] CD4⁺ T cells and B6 TCD-BM showed pathologic features similar to human chronic GVHD. The histologic findings of the skin (A-B), liver (C-D), and salivary glands (E-F) from recipients of [WT → C3H] CD4⁺ T cells with B6 TCD-BM and those of [H2-Ab1^−/− → C3H] CD4⁺ T cells with B6 TCD-BM are shown. Sclerodermatous skin changes, such as epidermal atrophy, fat loss, follicular dropout, and dermal thickness (B); bile duct loss and fibrosis in the portal area and mild periportal mononuclear infiltrates in the liver (D, arrow); and lymphocyte inflammation, fibrosis, and atrophy of acinar tissue in the salivary glands (F, arrow) were observed (original magnification, × 100).