Distribution of HAS1 GVs. (A) Cell type distribution of HAS1 GVs detected in patients with MM and WM. Mutations identified in various types of cells from patients with MM were classified as tumor specific, hematopoietic and germline–origin based on their occurrence in these cells. HPCs indicates CD34⁺45^low HPCs from mobilized blood of patients with MM or bone marrow aspirates from patients with WM; BECs indicate buccal epithelial cells. (B) Distribution of GVs in genomic HAS1. This figure shows relative distribution of GVs detected in patients with MM and WM. Recurrent NCBI-SNPs are absent from this figure. The inserts detail sets of GVs located at the boundary of exon 3 and exon 4, respectively. GVs are represented by yellow rings. On the figure, the first break on intron 4 represents 180 nucleotides, whereas the second break represents 100 nucleotides. 1st “T,” 2nd “T,” and “TTTA” are the common motif detected in patients with MM and WM. The spaces between mutations are arranged according to a scale of 50 bp = 4 mm.