Longitudinal analysis of viral load, B8-FL8 tetramer expression, and B8-FL8–specific Vβ repertoire. (A) Longitudinal analysis of HIV-1 RNA copies per milliliter of plasma, absolute numbers of CD4⁺ and CD8⁺ T cells, percentage of B8-FL8 tetramer–positive cells per peripheral CD8⁺ T cells, as well as the relative and absolute number of B8-FL8–specific Vβ populations in 3 untreated HIV-infected individuals (AC-14, AC-15, and AC-47). Days indicate time after diagnosis of acute HIV infection. (B) Longitudinal analysis of HIV-1 RNA copies per milliliter of plasma, percentage of B8-FL8 tetramer–positive cells per peripheral CD8⁺ T cells, and absolute number of B8-FL8–specific Vβ populations for an HIV-infected patient (AC-42) under antiretroviral treatment. (C) Longitudinal analysis as in panel A for an HIV-infected patient (AC-46) undergoing STI after a phase of optimal viral suppression under antiretroviral treatment.