Enzastaurin induces MM-cell apoptosis. (A) Dose-related effects of enzastaurin on survival of MM cell lines and healthy donors. PBMC indicates peripheral blood mononuclear cell. MTT cleavage was measured during the last 4 hours of 48-hour cultures. (B) Protein profiling of MM cells exposed to enzastaurin. MM.1S cells were exposed to increasing concentrations of enzastaurin, followed by immunoblot analysis of the lysates with indicated antibodies.