Figure 7
T cells from GCN2 KO mice proliferate in the absence of l-Arg. (A) T cells (2 × 105) were activated with bound anti-CD3 plus anti-CD28, and thymidine incorporation was tested after 48 hours (cpm ± SD). (B) Kinetics of expression of cyclin D3 and cdk4 in activated T cells (4 × 106) from GCN2 knock-out mice and congeneic wild-type mice.
