Integrated genomic analysis. The analysis shows chromosomal imbalances in 6 c-AML cases (A) and 5 CD4+CD56+HN cases (B). Green represents gains; red, losses of the corresponding chromosomal regions. (C) High-resolution analysis of chromosomes 9 and 13 for a representative individual case of CD4+CD56+HN. (D) Heat map depicting all significantly differentially expressed genes in CD4+CD56+HN versus c-AML within regions on chromosomes 9 and 13 that show recurrent chromosomal abnormalities. Arrows indicate known tumor suppressor genes and oncogenes; numbers correspond to cases described in Tables 1 and 2.