The response ofProcr^+/−mice to LPS challenge. (A) At 4 and 8 hours after LPS challenge, levels of APC in the plasma of Procr^+/− mice (n = 6 for each time point), ng/mL. (B) TAT, ng/mL. (C) APC/TAT. (D) Platelet counts, M/mL. (E) TNF-α, pg/mL. (F) IL-6, ng/mL. (G) The survival rates of Procr^+/+ mice (n = 16) and Procr^+/− mice (n = 16) are shown at 12 and 24 hours after LPS challenge. Results are presented as mean ± SD. *P < .05, compared with Procr^+/+ mice.