LAQ824 inhibits DC-mediated IFN-γ secretion from Th1 but not IL-4 production from Th2 cells. (A-B) IFN-γ and IL-4 secretion from DO11.10 Th1 (A) or Th2 (B) effector cells cocultured with bone marrow–derived DCs incubated with 0.1 mg/mL OVA and indicated stimuli. (C-D) IFN-γ and IL-4 secretion from DO11.10 Th1 (C) or Th2 (D) effector cells cocultured with bone marrow–derived DCs pulsed with 0.3 μM OVA peptide and indicated stimuli. Representative of 3 independent experiments.