Biologic effect of WNT pathway inhibition by DvL-2 targeting.(A) Treatment of Jeko-1 cells with siRNA for DvL-2 for 24 hours showed a dramatic decrease in the protein expression of DvL-2. (B) Wnt pathway inhibition by DvL-2 induced a significant decrease in Jeko-1 cell growth as measured by MTS assay. Error bars indicate SD. (C) Treatments of Jeko-1 cells for 48 hours with DvL-2 siRNA demonstrate a dose-dependent cleavage of caspase-3.