Bleeding times in wild-type or ADAP knockout mice. Tails of ADAP^+/+ or ADAP^−/− mice were warmed and then transected 0.5 mm from the end and immersed in 0.9% isotonic saline solution at 37°C. Blood flow was monitored, and the time when bleeding arrested initially was noted as the bleeding time. Tails were monitored further for a minimum of 60 seconds to determine if bleeding recurred. (A) Bleeding times ± standard error of the mean (SEM). (B) Percentage of mice that showed rebleeding. Results are calculated from measurements on a total of 33 ADAP^+/+ and 37 ADAP^−/− mice.