Model of cycle of CLL autoantigen stimulation. CLL B cell indicated by circle labeled with 3 Y-shaped antibodies and the number 5 (for CD5). Activated CLL B cells are striped. Boxes represent 2 cellular compartments: solid tissue, lymphoid organs such as bone marrow or lymph nodes, or blood. Other types of cells, possibly stromal cells as suggested in this illustration, present antigen represented by different shades and shapes. Sizes of pathway arrows indicate amount of cell traffic within and between compartments.