List of exon 12 NPM1 mutations so far identified in AML patients. Red coloring indicates nucleotides inserted by mutations; green, leucine-rich NES motif; violet, tryptophan (W) residues; L, leucine; C, cysteine; V, valine; M, methionine; and F, phenyl-alanine. Mutations A to F refer to those we originally identified.¹⁸  Mutations E to H refer to those we identified in childhood AML.⁹¹  Mutations J to Q refer to those subsequently identified in Falini et al.⁸⁴  Mutations Gm to Qm refer to those we identified in the protocol 99 of the German AML cooperative group.⁸⁰  Mutations 1, 3, 4, 6, 7, 12, 13, 10, and 14 are according to Dohner et al.⁸¹  Mutation I* is according to Verhaak et al.⁸²  *NM_002520. †Mutations G, I, H, and J are according to Suzuki et al.⁹³