Ribbon representation of ABL in complex with imatinib and PD180970. Shown is (A) the conformation of ABL (blue) in complex with imatinib (orange), with the activation loop (magenta) in the inactive conformation, and (B) ABL (green) in complex with a dual SRC/ABL inhibitor, PD180970 (red), with the activation loop (magenta) in the active conformation. Figure prepared by Sandra W. Cowan-Jacob based on reported structures.^60,61  Reprinted from Deininger et al.⁴¹