Schematic of point mutations in the ABL kinase domain. Mutations in the ABL kinase domain (amino acids 240 to 500) cluster in 4 distinct regions, the ATP-binding domain (amino acid 248-255, green), mutations of T315 (red), which form a hydrogen bond with imatinib, M351 (turquoise), which interacts with the SH2 domain and participates in autoregulation of kinase activity, and the activation loop (amino acids 379-398, magenta). The vertical lines represent the frequency each amino acid has been found to be mutated as compiled from the literature. Reprinted from Deininger et al.⁴¹