Figure 7
Figure 7. Optimal B-cell survival in response to TLR4 signaling. Optimal B-cell survival in response to TLR4 signaling involves Bim neutralization by a combination of degradation after Tpl2-dependent ERK phosphorylation, plus binding to the Bcl-2–like prosurvival proteins A1 and Bcl-xL, which are up-regulated by c-Rel–dependent transcription.

Optimal B-cell survival in response to TLR4 signaling. Optimal B-cell survival in response to TLR4 signaling involves Bim neutralization by a combination of degradation after Tpl2-dependent ERK phosphorylation, plus binding to the Bcl-2–like prosurvival proteins A1 and Bcl-xL, which are up-regulated by c-Rel–dependent transcription.

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