Cumulative incidence of MDS and AML in patients with aplastic anemia who were given or not G-CSF. Cytogenetic analysis failed or was not available in 26 patients. Among 18 patients with cytogenetic data, monosomy 7 was diagnosed in 6 cases, trisomy 8 was detected in 2 cases and other abnormalities in 3 cases. In MDS/AML cases G-CSF was delivered for 4.5 months as a median (range, 1-35 months) at the expected dose 5 μg/kg range (however, the exact dose was only known for 11 cases).