Treatment schedule. The VMPT schedule is based on bortezomib at 3 dose levels (1.0 mg/m2, 1.3 mg/m2, or 1.6 mg/m2) on days 1, 4, 15, and 22; melphalan at 6 mg/m2 on days 1 through 5, prednisone at 60 mg/m2 on days 1 through 5; and thalidomide at 50 mg on days 1 through 35. Each course was repeated every 35 days.