Probability of EFS and S of all patients and randomized patients. (A) Product-limit estimate of probability of EFS and S in all patients from study entry. EFS at 4 years, 79% ± 2.7%; S at 4 years, 82% ± 2.6%. (B) Product-limit estimate of probability of EFS from randomization of patients randomized to C1 versus C2 (mini CYVE and deletion M2, M3, M4 courses); EFS at 4 years 90% ± 3.1% versus 80% ± 4.2%, P = .064.