TKI258 inhibits proliferation and survival of Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1. Cells (■ Ba/F3-ZNF198-FGFR1 and ● Ba/F3-BCR-FGFR1 grown in the absence of IL3; ▴ Ba/F3-pcDNA3.1 grown in the presence of IL3) were exposed to TKI258 for 48 hours. Values are means plus or minus SE of 3 independent experiments.